Inositol Phosphates
For the best and the brightest, and the most highly phosphorylated
The schedule is based on CET (Central European Time)
Day 1
08.01.2025 (Wednesday)
13:00 pm Opening Comments (Nam, Deb, Henning)
13:05 pm
13:35 pm
13:55 pm
14:15 pm
14:20 pm
Keynote 1
"A lifetime of inositol phosphates: from forgotten biochemistry to pancreatic β-cell physiology"
Chris Barker
Karolinska / Sweden
Talk 1
"Appreciating the signaling versatility of 5-IP7 through its regulated synthesis and effector modulation"
Feng Rao
Sustech Shenzhen / China
Talk 2
"Ip6k1 and Ip6k2, phosphate sensing, and kidney tubule function"
Carsten Wagner
Uni Zürich / Switzerland
Elevator 1
"Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I"
Xiaoqi Liu
Tianjin medical university
Elevator 2
"Local synthesis of 5-InsP7 drives protein pyrophosphorylation"
Jayashree Ladke
CDFD / India
BREAK (14:25-14:59)
Session 1, Chair: Henning J.Jessen
Session 2, Chair: Rashna Bhandari
15:00 pm
15:20 pm
15:40 pm
16:00 pm
16:05 pm
16:10 pm
Talk 3
The role of intestinal microbial phytate metabolism in obesity and diabetes
Nam Bui
Amsterdam UMC / The Netherlands
Talk 4
The impact of InsPs in the carbon assimilation and adaptability to stress in green microalgae
Inmaculada Couso
Uni Sevilla / Spain
Talk 5
"Unexpected findings in inositol pyrophosphate metabolism from fungi"
Ronda Rolfes
Georgetown University / USA
Elevator 3
"Discovery and Characterization of Inositol-Tetrakisphosphate 1-Kinase via Biochemical and Biophysical Methods:
Martin Ng
National Cancer Insitute
Elevator 4
"Systematic Profiling of XPR1 and IP6K inhibitors in cancer"
Daniel Bondeson
UMass Chan Medical School
Elevator 5
"Multimodal regulation of IP6K1 by the E3biquitin ligase Ube4A via a unique mechanism"
Naga Lakshmi Challa
Saint Louis University School of Medicine
BREAK (16:15-16:39)
Session 3, Chair: Stewart Shuman
16:40 pm
17:00 pm
17:20 pm
Talk 6
"From Hypoxia to Normoxia via ITPP"
Jean-Marie Lehn
ISIS Strasbourg / France
Talk 7
"Role of inositol-tetrakisphosphate 1-kinase in cancer"
Ji Luo
Center for Cancer Research, NIH / USA
Talk 8
"IPMK regulates HDAC3 and histone H4 acetylation in human cells"
Ray Blind
Vanderbilt University / USA
CLOSE
Day 2
09.01.2025 (Thursday)
13:00 pm Opening Comments (Nam, Deb, Henning)
Session 4, Chair: Debabrata Laha
13:05 pm
13:35 pm
13:55 pm
14:15 pm
14:20 pm
Keynote 2
"Inositol polyphosphates: from fungal pathogenesis to drug development"
Julianne Djordjevic
University of Sydney / Australia
Talk 9
"Exploring IP7-regulated protein targets in mammals"
Seyun Kim
KAIST / South Korea
Talk 10
"Inositol phosphates trigger conformational changes of Arabidopsis phosphate transporter PHT5 in regulating vacuolar phosphate storage"
Tzyy-Jen Chiou
Academia Sinica / Taiwan
Elevator 6
"A key plant immune regulator intersects phosphate homeostasis"
Medha Noopur
Regional Centre for Biotechnology / India
Elevator 7
"Arabidopsis PFA-DSP2, a crucial phosphatase in inositol pyrophosphate catabolism, regulates phosphate transporter expression and phosphate homeostasis"
CHANG HAO-HSIANG
Agricultural Biotechnology Research Center/ Taiwan
BREAK (14:25-14:59)
Session 5, Chair: Michael Hothorn
15:00 pm
15:20 pm
15:40 pm
16:00 pm
16:05 pm
16:10 pm
Talk 11
"Inositol pyrophosphates - Regulators of plant root endosymbioses ?"
Martina Ried
Leibniz Institute Plant Biochemistry / Germany
Talk 12
"Using Native and Synthetic Genes to Disrupt Inositol Pyrophosphates and Phosphate Accumulation in Plants"
Catherine Freed
University of Wisconsin/ USA
Talk 13
"Role of novel Arabidopsis pyrophosphate phosphohydrolases in phosphate signaling and beyond"
Gabriel Schaaf
University of Bonn / Germany
Elevator 8
"A GAF domain controls PPIP5K phosphatase activity in phosphate homeostasis"
Pierre Raia
University of Geneva / Switzerland
Elevator 9
"13C-Labeled scyllo-inositol to investigate its metabolism in mammalian cells"
Meike Amma
FMP - Leibniz-Forschungsinstitut für Molekulare Pharmakologie / Germany
Elevator 10
"Teach an old turtle new tricks - chemoenzymatic synthesis of InsP derivatives"
Markus Häner
Albert-Ludwigs University Freiburg / Germany
BREAK (16:10-16:39)
Session 3
Session 6, Chair: Ursula Fleig
16:40
17:00 pm
17:20 pm
Talk 14
"Discovery of an Atypical Malaria Parasite Inositol Phosphatase"
Emily Derbyshire
Duke University / USA
Talk 15
"A to I RNA editing by ADAR1 is influenced by inositol hexaphosphate"
Fran Venegas Solis
University of Marburg / Germany
Talk 16
"Pairwise inactivation of inositol pyrophosphatases illuminates distinct mechanisms of inositol pyrophosphate toxicosis in fission yeast"
Beate Schwer
Weill Cornell Medical College / USA
CLOSE
Day 3
10.01.2025 (Friday)
13:00 pm Opening Comments (Nam, Deb, Henning)
Session 7, Chair: Nam Bui
13:05 pm
13:35 pm
13:55 pm
14:15 pm
14:20 pm
Keynote 3
"Phosphate homeostasis in yeast - strategies beyond InsPPs and SPX domains"
Andreas Mayer
University of Lausanne / Switzerland
Talk 17
"Binding of inositol pyrophosphates to VTC SPX domains studied by NMR spectroscopy"
Sebastian Hiller
Biocenter Basel / Switzerland
Talk 18
"Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based inositol pyrophosphate receptor XPR1"
Chunfang Gu
NIEHS NIH / USA
Elevator 11
"Orchestration of phosphate homeostasis by the ITPK1-type inositol phosphate kinase in the liverwort Marchantia polymorpha"
Naga Jyothi Pullagurala
Indian Institute of Science/ India
Elevator 12
"Tomato Myo-inositol Phosphate Synthase 2 regulates phosphate homeostasis in tomato seedlings"
Rahul Kumar
University of Hyderabad / India
BREAK (14:25-14:59)
Session 8, Chair: Bastien Castagner
15:00 pm
15:20 pm
15:40 pm
Talk 19
"Chemical Interactions and Hydration Patterns of Inositol Hexaphosphates"
Kristin Bowman-James
University of Kansas / USA
Talk 20
"Detection of endogenous protein pyrophosphorylation using mass spectrometry"
Dorothea Fiedler
FMP Berlin / Germany
Talk 21
"Nuclear Delivery of Inositol Pyrophosphate Prometabolites Mediated by Short Cationic Peptides"
Adeline Schmitt
ETH Zürich / Switzerland
BREAK (16:00-16:29)
Session 9, Chair: Henning J.Jessen
16:30 pm
16:50 pm
16:55 pm
17:00 pm
17:05 pm
16:30 pm
16:50 pm
Talk 22
"Transport and InsP8 activation mechanisms of the human inorganic phosphate exporter XPR1"
Melinda Diver
Sloan Kettering Institute / USA
Elevator 13
"Analysis of InsP1 and InsP2 in biosamples by CE-MS
Mengsi Lu
Albert-Ludwigs-University, Freiburg / Germany
Elevator 14
"Inositol pyrophosphate catabolism in Marchantia polymorpha
Felix Rico ResendizUniversity of Geneva / Switzerland
Elevator 15
"Structure-Guided Development of Inhibitors for Inositol Phosphate Kinases
Huanchen Wang
NIEHS/NIH / USA
Featured Talk
"The contribution of chromatography to inositol (pyro)phosphate enzymology of plants"
Charles Brearley
University of East Anglia / United Kingdom